结构神经成像表型和自闭症相关的分子和基因组基础:一篇综述
Charlotte M Pretzsch1, Christine Ecker2
1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Frontiers in neuroscience
|July 17, 2023
概括
这篇评论探讨了自闭症中发现的大脑差异,例如皮质厚度,与遗传变异的联系. 了解这些联系可以揭示自闭症.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 自闭症与神经解剖学发育的改变有关,包括皮质厚度,表面积和体积.
- 神经成像特征被认为是连接遗传变异与自闭症症状的中间表型.
研究的目的:
- 审查文献,将自闭症的神经解剖现象与生物过程和遗传变异联系起来.
- 从成像中获得的大脑特征到自闭症的基础生物学和遗传学的途径.
主要方法:
- 对现有关于神经解剖学,分子生物学和自闭症遗传学的研究进行系统审查.
- 分析体内和跨年龄数据以确定关联.
主要成果:
- 自闭症中的神经成像差异与特定的神经病理过程相关.
- 这些神经解剖学变异与潜在的遗传和表观遗传因素有关.
结论:
- 解开神经成像表型的分子和基因组基础对于理解自闭症病因至关重要.
- 从神经解剖学到生物学和遗传学的途径提供了对自闭症复杂性的洞察.
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