COVID-19后的嗅觉和神经认知:一个范围审查
Brandon J Vilarello1, Patricia T Jacobson2, Jeremy P Tervo1
1Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States.
Frontiers in neuroscience
|July 17, 2023
概括
患有嗅觉功能障碍的COVID-19幸存者经常经历较差的神经认知. 本综述强调了感染后成年人嗅觉丧失和认知缺陷之间的联系,表明需要进一步研究.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 众所周知,COVID-19会导致神经系统并发症,包括感官变化.
- 嗅觉功能障碍 (嗅觉丧失) 是COVID-19的常见症状,可能表明更广泛的神经影响.
- 有证据表明,化学感官变化与神经退行性疾病中中枢神经系统功能障碍有关.
研究的目的:
- 审查和综合现有关于COVID-19后成年人神经认知和嗅觉之间的关系的文献.
- 为了评估COVID-19感染后的嗅觉功能障碍是否与年轻到中年成人具有最小的并发症的认知障碍相关.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 中进行了全面的文献搜索.
- 符合条件的研究经过了严格的选和数据提取,由多个审查者来确保可靠性.
- 在最终分析中包括了17项研究.
主要成果:
- 大多数审查的研究 (117项中的12项) 显示,COVID-19后嗅觉功能障碍患者的认知功能较差.
- 四项研究发现认知和嗅觉之间没有显著的关联.
- 一项研究报告说,在认知障碍患者中,厌氧症 (完全的嗅觉丧失) 的患病率较低.
结论:
- 目前的证据主要表明,COVID-19感染后嗅觉功能障碍和认知障碍之间存在关联.
- 需要进一步进行高质量的研究,以充分理解COVID-19后神经效应的背景下,嗅觉和认知之间的复杂关系.
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