初级Sjögren综合征的死亡风险因素:一个现实世界,回顾性,队列研究
Pilar Brito-Zerón1, Alejandra Flores-Chávez2, Ildiko Fanny Horváth3
1Autoimmune Diseases Unit, Research and Innovation Group in Autoimmune Diseases, Sanitas Digital Hospital, Hospital-CIMA-Centre Mèdic Milenium Balmes Sanitas, Barcelona, Spain.
EClinicalMedicine
|July 17, 2023
概括
初级Sjögren综合征 (SjS) 的死亡率是由高系统活性 (ESSDAI) 和阳性冷球蛋白预测的. 这些因素显著增加了死亡风险,突出了在诊断时评估这些因素的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 关于初始Sjögren综合征 (SjS) 死亡率的基线预测因素存在不确定性.
- 识别死亡风险因素对于管理SjS患者至关重要.
- 这项研究调查了与SjS死亡率相关的基线特征.
研究的目的:
- 确定初始Sjögren综合征所有原因死亡率的基线预测因素.
- 确定与系统性SjS活动相关的死亡风险因素.
- 分析诊断时疾病表型与死亡结果之间的关联.
主要方法:
- 国际,现实世界,回顾性队列研究,使用大数据Sjögren注册表.
- 包括符合2002/2016年SjS分类标准的患者.
- 定向非循环图统计方法分析所有原因和与SjS相关的死亡率.
主要成果:
- 较高的DAS-ESSDAI得分和阳性冷球蛋白分别预测了所有死因的死亡 (HR=1.68和HR=1.72).
- 异常的口腔测试,高的DAS-ESSDAI和阳性冷球蛋白预测了与SjS相关的死亡 (HR=1.38,HR=1.55,HR=1.52).
- 高ESSDAI分数和阳性冷球蛋白增加了两倍的死亡风险.
结论:
- 阳性冷球蛋白和高系统活性 (ESSDAI) 是SjS诊断时的关键死亡风险因素.
- 建议在SjS诊断时进行ESSDAI测量和冷球蛋白测试.
- 这些因素显著增加了所有原因和与SjS相关的死亡风险.
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