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树提取物改善了与动脉样硬化相关的内皮功能障碍的分子标志物

Joseph Festa¹, Aamir Hussain¹, Amon Hackney¹

¹Leicester School of Allied Health Sciences De Montfort University Leicester UK.

Food science & nutrition

|July 17, 2023

概括

树提取物 (EB) 通过减少氧化应激和炎症来保护内皮功能障碍. 这项研究表明,EB改善了内皮功能标志物,表明它有预防动脉样硬化的潜力.

科学领域:

血管生物学血管生物学
营养科学营养科学
细胞生物学细胞生物学

背景情况:

内皮功能障碍 (ED) 是动脉样硬化的早期标志物,与减少的氧化 (NO) 和氧化应激有关.
减少NO的生物可用性促进单细胞粘附和动脉样硬化发展.
长树提取物 (EB),富含安东素,可以提供血管保护作用.

研究的目的:

研究EB对内皮功能障碍标志物的影响.
评估EB对细胞活力,细胞亡和内皮细胞中氧化应激的影响.
评估EB在防止单细胞粘附到内皮细胞方面的潜力.

主要方法:

人类静脉内皮细胞 (HUVEC) 经过EB预处理,并用TNF-α刺激.
评估了细胞活力,细胞亡,氧化应激以及ENOS,Akt,Nrf2,NOX-4和NF-κB的蛋白质水平.
使用共同培养模型测量单细胞粘附和粘附分子 (VCAM-1) 和细胞因子 (IL-6,MCP-1) 的表达.

主要成果:

在HUVEC中,EB阻止了TNF-α诱导的亡和反应性氧物种的产生.
在EB上调节了Akt,eNOS和Nrf2,同时降低了NOX-4和NF-κB活动.
EB抑制了单细胞对HUVEC的粘附,减少了IL-6,MCP-1和VCAM-1的表达.

结论:

EB增强内皮功能关键细胞标志物,并减轻内皮功能障碍的标志物.
乙烯基乙烯显示出作为预防动脉样硬化进展的营养辅助的潜力.

关键词:

它们是安托西安氨酸.动脉样硬化动脉样硬化长老的果长老的果内皮质功能障碍内皮质功能障碍体内氧化合成酶的作用.

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