对急性髓性白血病有效的植物化学物质和生物活性化合物:系统性审查
Chukwuebuka Egbuna1,2,3, Kingsley C Patrick-Iwuanyanwu1,2, Eugene N Onyeike1,2
1Africa Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR) University of Port Harcourt Port Harcourt Nigeria.
Food science & nutrition
|July 17, 2023
概括
这次审查强调了60多种生物活性化合物,这些化合物有可能成为新型急性髓性白血病 (AML) 治疗方法. 这些化合物提供了各种机制来打击AML治疗中的耐药性和复发.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 急性髓性白血病 (AML) 是一种复杂的血液癌症,其特征是细胞异常发育和死亡.
- 尽管化疗和向疗法取得了进展,但AML治疗仍面临着耐药性和疾病复发的挑战.
- 识别新型治疗剂对于改善患者的治疗结果至关重要.
研究的目的:
- 系统地审查和识别具有针对AML潜在抗白血病特性的生物活性化合物.
- 将这些化合物分类并探索它们的多样化作用机制.
主要方法:
- 在PubMed/MEDLINE,ScienceDirect和谷歌学者中进行了系统的文献搜索.
- 选了518篇文章,其中59篇被选择用于数据提取和分析.
- 生物活性化合物被确定并分为主要组.
主要成果:
- 确定了60多种具有抗白血病潜力的生物活性化合物.
- 化合物被分为五组:黄类,类,有机硫化合物,类/类等.
- 作用机制包括染色质破坏,亡诱导和抑制Hsp90和DNA甲基转移酶1等关键酶.
结论:
- 许多生物活性化合物显示出作为急性髓性白血病的新疗法的前景.
- 这些化合物表现出多种机制,提供了克服AML耐药性和复发的潜在策略.
- 对这些化合物的进一步研究可能会导致开发新的AML药物.
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