针对非典型的甲状腺性拉布瘤 (ATRT) 的免疫疗法的当前进展
Son Tran1, Ashley S Plant-Fox2, Susan N Chi3
1Departments of Oncology and Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Neuro-oncology practice
|July 17, 2023
概括
非典型的形形形瘤 (ATRT) 是需要新治疗的侵袭性儿科脑瘤. 本综述探讨了ATRT的免疫疗法和表观遗传策略,为改善患者的治疗结果提供了希望.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 免疫学 免疫学 免疫学
背景情况:
- 非典型的甲状腺瘤 (ATRT) 是一种罕见的,具有侵略性的胚胎中枢神经系统瘤,主要影响幼儿.
- 目前对ATRT的治疗与糟糕的结果和显著的毒性有关,需要新的治疗策略.
- 最近了解ATRT分子和遗传特征的进展为包括免疫疗法在内的向疗法开辟了道路.
研究的目的:
- 审查目前对ATRT及其亚型中的瘤免疫微环境的理解.
- 总结ATRT新出现的临床和临床前免疫疗法数据.
- 在ATRT中突出表观遗传学在免疫调节中的作用,以告知未来的治疗开发.
主要方法:
- 关于ATRT瘤免疫学和免疫治疗的综合文献综述.
- 对ATRT分子和遗传特征的现有数据的分析.
- 综合有关表观遗传修饰及其对ATRT免疫力影响的信息.
主要成果:
- 越来越多地描述了ATRT的瘤免疫微环境,揭示了免疫调节的潜在目标.
- 早期的临床和临床前研究表明,在ATRT中,基于免疫治疗的方法具有前景.
- 表观遗传失调显著影响ATRT中的免疫格局,为治疗干预提供了机会.
结论:
- 免疫疗法是治疗ATRT的有希望的新方法,解决了传统疗法的局限性.
- 了解ATRT中表观遗传学和免疫系统之间的相互作用对于开发有效的免疫治疗策略至关重要.
- 对ATRT的免疫微环境和表观遗传景观的进一步研究将指导下一代治疗的开发.
更多相关视频
12:55Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.5K
11:15Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
8.0K
相关概念视频
01:27Tumor Immunotherapy
567
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
567
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K