有效地利用公开可用的数据库进行癌症目标评估
Daniel Croft1, Puja Lodhia2, Sofia Lourenco2
1Cancer Research Horizons, The Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.
NAR cancer
|July 17, 2023
概括
发现有效的癌症药物需要强大的目标评估,以减少失败率. 这项研究强调了关键的,可访问的数据库,用于从各种研究中挖掘关键数据,以帮助精准医学的发展.
科学领域:
- 在瘤学瘤学.
- 药物发现 药物发现 药物发现
- 生物信息学是一种生物信息学.
背景情况:
- 大多数癌症候选药物由于效率差或毒性不足而失败.
- 有效的目标评估至关重要,以尽量减少药物发现的消耗.
- 公开可用的数据库为目标评估提供了有价值的数据,但导航可能具有挑战性.
研究的目的:
- 编制和提供关键的,可自由访问的癌症目标评估数据库.
- 引导研究人员了解这些数据库的使用和局限性.
- 支持在瘤学领域发展精准医学.
主要方法:
- 文献审查和公开可用的数据库的编译.
- 基于数据类型的数据库的分类 (体外,体内,临床).
- 确定全面目标审查数据库.
主要成果:
- 这里列出了针对癌症目标评估的可访问数据库的精选列表.
- 突出显示了包含体外,体内和临床研究数据的数据库.
- 确定了从多个来源整合信息的一站式门户.
结论:
- 使用这些突出显示的数据库可以显著帮助癌症目标评估.
- 有效的数据库挖掘支持精准医学的进步.
- 该资源旨在减少癌症药物发现中的高消耗率.
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