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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
394
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

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相关实验视频

Updated: Jul 23, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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有效地利用公开可用的数据库进行癌症目标评估.

Daniel Croft1, Puja Lodhia2, Sofia Lourenco2

  • 1Cancer Research Horizons, The Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.

NAR cancer
|July 17, 2023
PubMed
概括

发现有效的癌症药物需要强大的目标评估,以减少失败率. 这项研究强调了关键的,可访问的数据库,用于从各种研究中挖掘关键数据,以帮助精准医学的发展.

科学领域:

  • 在瘤学瘤学.
  • 药物发现 药物发现 药物发现
  • 生物信息学是一种生物信息学.

背景情况:

  • 大多数癌症候选药物由于效率差或毒性不足而失败.
  • 有效的目标评估至关重要,以尽量减少药物发现的消耗.
  • 公开可用的数据库为目标评估提供了有价值的数据,但导航可能具有挑战性.

研究的目的:

  • 编制和提供关键的,可自由访问的癌症目标评估数据库.
  • 引导研究人员了解这些数据库的使用和局限性.
  • 支持在瘤学领域发展精准医学.

主要方法:

  • 文献审查和公开可用的数据库的编译.
  • 基于数据类型的数据库的分类 (体外,体内,临床).
  • 确定全面目标审查数据库.

主要成果:

  • 这里列出了针对癌症目标评估的可访问数据库的精选列表.
  • 突出显示了包含体外,体内和临床研究数据的数据库.
  • 确定了从多个来源整合信息的一站式门户.

结论:

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  • 使用这些突出显示的数据库可以显著帮助癌症目标评估.
  • 有效的数据库挖掘支持精准医学的进步.
  • 该资源旨在减少癌症药物发现中的高消耗率.