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结合从沃顿果和胚胎生物材料支架中提取的中酶体干细胞,用于细胞输送

Umamagesh Palaniappan^1,2, Jaianand Kannaiyan^3,4, Balaji Paulraj⁵

¹PG and Research Centre in Microbiology, MGR College, Hosur 635130, Tamil Nadu, India.

|July 17, 2023

概括

人类沃顿的人类沃顿

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
干细胞生物学干细胞生物学

背景情况:

介酶干细胞疗法在组织再生方面表现有前途.
在追踪和保留受伤部位的细胞方面存在挑战.
生物相容的支架为细胞输送提供了一个潜在的解决方案.

研究的目的:

为了评估人类沃顿果衍生的介质干细胞 (WJMSCs) 在生物膜上的反应.
为了确定一个适合的再生支架,用于支架细胞的输送,以增强愈合.
优化组织工程构造变量,以提供WJMSC.

主要方法:

对WJMSCs的隔离和表征.
播种WJMSCs在基于胎膜的支架上.
细胞播种效率,分散,粘附,生存和代谢活动的体外评估.

主要成果:

胚胎膜支架在体外显著改善了WJMSC的播种效率,分散,粘附,生存和代谢活动.
证明了WJMSCs与生物膜支架之间的积极相互作用.
提供了关于细胞集成支架性能的定量数据.

结论:

基于胚胎膜的支架有效地支持WJMSC在体外的行为.
这项研究突出了用于组织再生应用的新型支架材料.
该方法可用于评估其他脚手架材料,以提高WJMSC的愈合潜力.

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...