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同时双对比增强使用Fe₃O₄纳米粒子实现CEST信号可控性

Feixiang Hu¹, Dan Wang², Xiaowen Ma¹

¹Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China 200032.

|July 17, 2023

概括

这项研究开发了新的氧化铁纳米颗粒 (Fe3O4 NPs) 用于双T2/CESTMRI对比. 这些无毒的NP能够同时进行成像和pH测绘,从而增强瘤的可视化和评估.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
磁共振成像 (MRI) 是一种磁共振成像技术.

背景情况:

传统的T2MRI对比剂有其局限性.
化学交换和转移 (CEST) 剂量化微量物质.
基于铁的对比剂可以在足够的度下抑制CEST信号.

研究的目的:

开发一个可控制尺寸的T2MRI阴性对比剂.
通过结合T2和CEST代理来探索双重对比增强.
研究使用Fe3O4纳米粒子用于双模式MRI的可行性.

主要方法:

合成的Fe3O4纳米粒子 (NP) 具有可控制的大小和表面功能.
使用 3.0 T MRI 扫描仪进行 CEST 和 MAGiC 成像.
通过电子显微镜,光谱,DLS,ICP,XRD,VSM和细胞测定来评估NP特征.

主要成果:

成功合成了在酸性环境中自我聚合的无毒Fe3O4NP (82.6 ± 22.4 nm).
证明了双模式成像能力,其中Fe3O4NP作为T2对比剂,并使基于CEST的pH映射成为可能.
在度≥30μg/mL时,Fe3O4NP抑制了CEST信号,使同时成像和pH映射成为可能.

结论:

Fe3O4NP为MRI提供了一个有前途的双对比度增强方法.
开发的NP允许同时进行T2/CEST成像和体外pH测绘.
这种方法为瘤疗效评估和成分识别提供了一种新的方法.

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