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一个意外的皮肤血管炎的病例,在注射佐勒德龙酸后
Bita Zahedi1, Zachary S Wallace2, Maya McEwen Côté1
1Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
JCEM case reports
|July 17, 2023
概括
黄酸 (Zol) 输液很少会导致皮肤小血管血管炎 (SVV). 这一案例突出了对Zol的潜在特异反应,呈现为明显的紫外线和升高的肝酶,成功地用普雷尼松治疗.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 佐勒龙酸 (Zol) 是一种双酸盐药物,通常用于骨质疏松症和骨转移.
- 对双酸盐的不良药物反应虽然很少见,但可以包括各种系统和皮肤表现.
- 小血管血管炎 (SVV) 是一组由小血管炎症为特征的疾病.
研究的目的:
- 报告一种罕见的孤立皮肤小血管血管炎 (SVV) 病例,该病例发生在注射索莱德龙酸 (Zol) 后.
- 为了突出对双酸盐疗法的特异反应的潜力.
- 提高临床医生对Zol.这种潜在的不良影响的认识.
主要方法:
- 一个58岁的绝经后妇女的病例报告.
- 详细的临床观察Zol输液后的症状.
- 实验室调查,包括肝功能测试和维生素D水平.
- 基于临床表现和时间线的皮肤SVV诊断.
- 用普得尼松治疗逐渐减少.
主要成果:
- 患者在Zol输液后几个小时内出现了扩散性水性腹,肌痛和皮肤敏感.
- 逐渐发展的非白色,可触摸的紫外线在下肢.
- 在第10天发现肝酶 (AST和ALT) 升高.
- 对皮肤SVV的诊断,被认为是对Zol.Zol.的特异反应.
- 用普得尼松缓和剂成功治疗.
结论:
- 隔离性皮肤小血管血管炎 (SVV) 是索莱德龙酸 (Zol) 治疗的潜在罕见并发症.
- 这种情况表明,Zol.对Zol.的特异性药物反应.
- 临床医生应考虑Zol作为皮肤SVV的潜在原因,在患者呈现与相容的症状.
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