纳米粒子诱导的人类健康的潜在毒性:应用,毒性机制和评估模型
Lihui Xuan1, Zhao Ju1, Magdalena Skonieczna2,3
1Department of Occupational and Environmental Health Xiangya School of Public Health Central South University Changsha Hunan China.
MedComm
|July 17, 2023
概括
本综述探讨了纳米粒子 (NP) 在健康中的应用及其毒理学. 它详细介绍了NP对各种身体系统,毒性机制和评估模型的影响,解决了NP风险评估中的知识差距.
科学领域:
- 纳米技术纳米技术
- 毒理学 毒理学 毒理学
- 生物医学科学 生物医学科学
背景情况:
- 纳米粒子 (NP) 被广泛研究,但了解它们的健康风险,毒理机制和评估模型仍然不完整.
- 现有的研究往往缺乏健康毒理学的深度,阻碍了对NP风险的全面理解.
研究的目的:
- 为健康提供NP应用的全面概述,重点是医学诊断和治疗.
- 详细介绍NP在各种生理系统中的毒性及其致癌潜力.
- 阐明NP毒性的潜在机制,并引入各种评估模型.
主要方法:
- 在健康领域对NP应用的文献综述.
- 在呼吸,神经,内分泌,免疫和生殖系统中对NP毒性的详细分析.
- 探索NP毒性机制,包括氧化应激,炎症,亡和DNA损伤.
- 介绍和比较经典的 (细胞系,小鼠) 和新兴的 (3D有机体) NP评估模型.
主要成果:
- 核皮肤具有多种健康应用,特别是在诊断和治疗方面.
- NP在多个器官系统中表现出毒性,具有潜在的致癌性.
- 关键的毒性机制包括ROS积累,线粒体损伤,炎症,亡,DNA损伤,细胞循环中断和表观遗传变化.
- 传统和新型模型都用于NP毒性评估.
结论:
- 本综述批判性地总结了NP毒理学的当前知识,突出了关键的差距.
- 它提供了对NP风险,机制和评估方法的更好理解.
- 这些发现旨在指导未来的研究,以实现更强大的NP安全评估.
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