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双样本孟德尔随机化检测出肠道微生物群和腹腔疾病在具有高遗传风险的个体之间的双向因果关系

Bárbara P González-García¹, Sergi Marí¹, Ariadna Cilleros-Portet¹

¹Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces Bizkaia Health Research Institute, Leioa, Spain.

Frontiers in immunology

|July 17, 2023

概括

肠道微生物组和腹病 (CeD) 在基因风险人群中具有复杂的双向关系. 某些肠道细菌可能会导致CeD,而这种疾病也可能改变肠道细菌的组成.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

病 (Celiac Disease,简称CeD) 是一种自身免疫性疾病,在遗传敏感的个体中由质触发.
具有人类白细胞抗原 (HLA) DQ2.5亚型的个体具有CeD的最高遗传风险.
改变肠道微生物群 (GM) 在高风险个体和患有CeD的人群中被观察到,但因果关系尚不清楚.

研究的目的:

在高遗传风险 (HLA-DQ2阳性) 个体中调查肠道微生物群和CeD之间的潜在双向因果关系.

主要方法:

进行了双向的双样本孟德尔随机化 (2SMR) 分析.
利用了基因组广泛关联研究 (GWAS) 的转基因和CeD总结统计数据.
该研究测试了GM作为暴露和CeD作为结果,反之亦然,以评估两个方向的因果关系.

主要成果:

在Ruminococcaceae和Lachnospiraceae家族 (Firmicutes phylum) 内的几种细菌被确定为可能导致CeD的细菌,并被它改变.
变化Veillonellaceae家族的丰富性可能因果导致CeD的发展.
帕斯托雷拉家族丰度的变化可能是CeD的结果.

结论:

在HLA-DQ2高风险个体中,肠道微生物群和CeD之间的关系是复杂的,双向的.
这些发现突显了肠道微生物组与自身免疫性疾病发展之间的复杂相互作用.

关键词:

在HLA-DQ2中.门德尔的随机化这是双向因果关系.患有乳性疾病的患者.我们的肠道微生物群.

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