基于mRNA的SARS-CoV-2 Comirnaty疫苗在没有先前感染的个体中引起了弱和短的特异性记忆B细胞反应
José L Casado1,2, Pilar Vizcarra1,2, Adrián Martín-Hondarza3
1Department of Infectious Diseases, CIBERINFEC (Biomedical Research Center Network in Infectious Diseases), Madrid, Spain.
接种SARS-CoV-2疫苗会启动记忆B细胞 (MBCs),但没有先前感染的个体表现出较弱的反应. 在先前没有感染的个体中,这种麻木的MBC免疫力与突破性感染的更高风险有关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在SARS-CoV-2疫苗接种后评估长期免疫力需要了解记忆B细胞 (MBC) 动态.
- 对于评估疫苗有效性来说,比较感染先前和已康复个体之间的MBC反应至关重要.
研究的目的:
- 为了比较SARS-CoV-2未暴露的与康复的个体在mRNA疫苗接种后的尖端特异性MBC反应.
- 调查这些MBC反应对突破性SARS-CoV-2感染的影响.
主要方法:
- 一项纵向队列研究,涉及85名先天和64名康复参与者.
- 在两剂mRNA疫苗接种前和后量化尖端特异性MBC和T细胞.
- 分析MBC同型 (IgG,IgM,IgA) 和与感染结果的相关性.
主要成果:
- 与康复者相比,原始个体在接种疫苗后表现出明显较低的尖端特异性MBC水平.
- 在未暴露组中观察到所有异型MBC反应的减少.
- 较低的MBC大小与接种疫苗后的时间相反相关,并且与突破性感染风险相对正相关,特别是IgA+和IgG+同型.
结论:
- mRNA疫苗接种对MBCs进行了原始化,但在SARS-CoV-2之前没有接种过的个体表现出了特定的MBC反应.
- 在以前没有感染的个体中,这种减少的MBC反应与突破SARS-CoV-2感染的时间更短有关.
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