在抑郁症中完全睡眠剥夺后,白质的微观结构乱
Brandon Taraku1, Artemis Zavaliangos-Petropulu1, Joana R Loureiro1
1Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, CA, United States.
Frontiers in psychiatry
|July 17, 2023
概括
总睡眠不足 (TSD) 在抑郁症患者中迅速改变白质 (WM) 微观结构,与健康对照群不同. 这些TSD诱导的WM变化可能解释了在抑郁症中观察到的快速抗抑郁药效应.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 总睡眠剥夺 (TSD) 暂时改善抑郁症状.
- 对于TSD对白质 (WM) 微观结构的影响,可能与其抗抑郁作用有关,尚不清楚.
研究的目的:
- 研究TSD如何影响抑郁症患者的WM微观结构的扩散张力成像 (DTI) 测量.
- 将这些变化与健康对照 (HCs) 中观察到的变化进行比较.
主要方法:
- 48名患有抑郁症的患者和53名HC患者在TSD之前和之后接受了扩散权重成像和情绪/反评估.
- 基于通道的空间统计 (TBSS) 分析了WM通路中的分数异构 (FA) 的声音变化.
主要成果:
- 患者在TSD后表现出显著的情绪和反改善 (p < 0.001).
- 患者在后应激障碍 (p <0.05,经校正) 后的体和前冠状辐射体中表现出降低的FA (p <0.05).
- 在患者和HC之间观察到TSD对FA的不同影响,在上方冠状状辐射,前方WM和后方乳头辐射 (p <0.05,校正) 中.
结论:
- 与HC相比,TSD在抑郁症患者中诱导了快速,明显的WM微结构变化.
- 像上冠状辐射和后丘脑辐射这样的WM通道可以作为TSD治疗效果的生物标志物.
- 上方冠状线辐射FA的变化与患者的反减少有关.
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