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EPD1504:一种新的μ-阿片类受体局部激动剂减弱了强迫症 (OCD) 类行为
Beth Youngblood1, Julio C Medina2, Donald R Gehlert1
1Epiodyne, Inc., San Francisco, CA, United States.
Frontiers in psychiatry
|July 17, 2023
概括
一种新的μ-阿片类受体 (MOR) 部分激动剂,EPD1504,有效地治疗强迫症 (OCD) 类似的行为,在老鼠中改善了安全性. 这可能为治疗耐药的强迫症患者提供比布诺芬更安全的替代品.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 低剂量的μ-阿片类受体 (MOR) 激动剂在耐治疗强迫症 (OCD) 中显示出快速的疗效,但安全问题限制了它们的使用.
- 布普伦诺芬是一种用于阿片类药物使用障碍的MOR部分激动剂,在治疗耐药的强迫症患者中显示出迅速的症状改善.
- 开发具有更好的安全概况的MOR激动剂对于扩大强迫症治疗选择至关重要.
研究的目的:
- 评估一种新型的MOR部分激动剂EPD1504,其在治疗强迫症类似行为的有效性和安全性.
- 在临床前的强迫症模型中,将EPD1504与布普伦诺芬和素的治疗效果和安全概况进行比较.
主要方法:
- 评估了EPD1504和布普伦诺芬在强迫症类行为的老鼠模型中的有效性 (操作概率逆转任务,大理石埋葬).
- 评估了有效的EPD1504剂量在正常和高的条件下对运动运动活动和呼吸的影响.
- 在有条件的位置偏好试验中比较EPD1504和布普伦诺芬,以评估滥用潜力.
主要成果:
- 在剂量占据MORs的20%的EPD1504和布普伦诺芬,在改善强迫症类行为方面与fluoxetine一样有效.
- 有效剂量的EPD1504并没有影响运动活动或呼吸,即使在超的条件下.
- 在有条件的位置偏好试验中,EPD1504显示了与布普伦诺芬相似的效果.
结论:
- 在强迫症类似行为的临床前模型中,EPD1504表现出显著的疗效.
- 与布普伦诺芬相比,EPD1504具有更好的呼吸安全概况.
- EPD1504代表了一种有希望的,可能更安全的替代方案来治疗耐治疗的强迫症.
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