在双边卵巢切除术后发生骨折的风险
Trine K Hueg1,2, Martha Hickey3, Astrid L Beck1,2
1Department of Growth and Reproduction Copenhagen University Hospital - Rigshospitalet Copenhagen Denmark.
JBMR plus
|July 17, 2023
概括
双边卵巢切除术 (手术切除两个卵巢) 并没有显著增加丹麦护士的脆弱性骨折风险. 这一发现无论手术时的年龄,荷尔蒙疗法或其他生活方式因素如何,都适用,这表明没有直接联系.
科学领域:
- 骨健康和骨质疏松症研究
- 生殖内分泌学和手术生殖内分泌学和手术
- 年龄相关骨折的流行病学.
背景情况:
- 在绝经后的妇女中,脆弱性骨折很常见,约有10分之一的丹麦50岁以上女性患有骨折.
- 双边卵巢切除术,即手术切除两个卵巢,可能会增加由于突然失去雌激素而导致脆弱性骨折的风险.
- 了解双边卵巢切除术对骨折风险和潜在的改变因素的具体影响,对于妇女的骨健康至关重要.
研究的目的:
- 调查双边卵巢切除术与发生脆弱性骨折的风险之间的关联.
- 为了确定这种关联是否因卵巢切除时的年龄,激素治疗使用,子宫切除,体力活动,BMI或吸烟状况而改变.
主要方法:
- 一项包括25853名丹麦护士队列中的女性护士 (年龄≥45岁) 的队列研究.
- 随访从50岁或队列进入到2018年12月31日,针对事件脆弱性骨折 (任何和特定地点).
- 用年龄作为时间尺度的考克斯回归模型来分析时间变化的双边卵巢切除暴露和骨折结果,使用来自全国患者登记册的数据.
主要成果:
- 1938年的护士 (7.5%) 接受了双侧卵巢切除术,6600名 (25.5%) 在491,626人年中经历了脆弱性骨折.
- 在卵巢切除后51岁以下患者中,脆弱性骨折的发生率为24.1%,在51岁以上患者中为18.1%.
- 在双边卵巢切除术 (任何年龄) 和任何部位的脆弱性骨折之间没有发现统计学上显著的关联. 对于HT,子宫切除术,体力活动,BMI或吸烟的修饰作用并不显著.
结论:
- 双边卵巢切除术,无论手术时的年龄,在这个丹麦护士队伍中都没有与脆弱性骨折的风险增加有关.
- 诸如使用激素治疗,子宫切除术,体力活动,BMI和吸烟等因素并没有改变观察到的关系.
- 这些发现表明,单独的双侧卵巢切除术可能不是45岁以上女性脆弱性骨折的重要独立风险因素.
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