通过饮食调节的肠道微生物群来调节SARS-CoV-2感染
Vivian Tieu1, Sedra Tibi1, Jun Ling1
1Department of Medical Education, California University of Science and Medicine, School of Medicine, Colton, CA, United States.
Frontiers in cellular and infection microbiology
|July 17, 2023
概括
肠道微生物群通过肠肺轴影响COVID-19的严重程度和免疫反应. 肠道微生物的饮食调节可能会影响冠状病毒疾病2019的易感性和治疗结果.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 的发病因子仍然不完全理解.
- 肠道微生物群与宿主免疫相互作用,与受COVID-19影响的系统重叠.
- 肠肺轴是微生物对呼吸道感染影响的关键途径.
研究的目的:
- 分析肠道微生物群在COVID-19病变发生中的作用.
- 研究肠道微生物群如何调节免疫系统对SARS-CoV-2的反应.
- 探索饮食对肠道微生物群和COVID-19结果的影响.
主要方法:
- 审查有关肠道微生物群,免疫系统和COVID-19的现有文献.
- 在SARS-CoV-2感染中对肠肺轴的分析.
- 讨论影响肠道微生物群组成和功能的饮食因素.
主要成果:
- 肠道失调和改变的微生物代谢物可以影响COVID-19患者的免疫系统.
- 肠道中的ACE2表达可能受到微生物群的调节,从而影响SARS-CoV-2.
- 老年人和患有并发症的人表现出与肠道菌群变化相关的敏感性增加.
结论:
- 肠道微生物群在调节对SARS-CoV-2感染的免疫反应方面发挥着重要作用.
- 针对肠道微生物群的饮食干预措施可能为管理COVID-19易感性,严重性和治疗提供策略.
- 了解肠肺轴对于开发COVID-19新型治疗方法至关重要.
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