豆纤维补充剂在接受血液透析的成年人中不会调节尿素代谢物:一项随机,双盲,受控试验
Asmaa M N Fatani1,2, Joon Hyuk Suh1, Jérémie Auger3
1Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, United States.
Frontiers in nutrition
|July 17, 2023
概括
豆体纤维 (PHF) 补充剂在血液透析患者中没有减少尿素分子. 肠道微生物群分析显示,有益细菌没有显著变化,这表明PHF在使用的剂量下可能不有效.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 食纤维被探索为一种治疗策略,以减少微生物产生的尿性毒素.
- 尿素分子,如p-cresyl硫酸盐和氧硫酸盐,与病患者的不良健康结果有关.
研究的目的:
- 调查豆纤维 (PHF) 补充剂在降低血清尿素分子水平方面的疗效.
- 确定PHF是否调节血液透析患者的肠道微生物群组成和活性.
主要方法:
- 采用了一种随机,双盲,受控交叉研究设计.
- 参与者每天摄入15克PHF或对照蛋糕4周,有4周的洗期.
- 使用LC-MS/MS和16SrRNA测序分析了血清尿素分子 (PCS,IS,PAG,TMAO) 和便微生物群.
主要成果:
- 补充PHF (15g/d) 并没有显著改变向尿素分子 (PCS,IS,PAG,TMAO) 的血清水平.
- 关键的与健康相关的肠道细菌 (例如,Akkermansia muciniphila,Faecalibacterium prausnitzii) 的相对丰度没有显著变化.
- 机器学习识别了PHF的独特微生物概况,显示了Gemmiger和Collinsella的丰富,以及Lactobacillus,Ruminococcus,Coprococcus和Mogibacteriaceae的枯竭.
结论:
- 在血液透析患者中,每天15g的豆纤维补充剂没有有效地减少血清尿素分子.
- 在测试剂量下,PHF的高纤维素含量可能会限制其发酵和随后对微生物群组成和尿素毒素产生的影响.
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