双杆菌和细菌体和母乳寡糖体之间的相互作用及其与婴儿认知的关联
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Updated: Jul 23, 2025

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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
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Seoyoon Cho1, Tinu M Samuel2, Tengfei Li3,4
1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Frontiers in nutrition
|July 17, 2023
概括
这项研究表明,母乳寡糖和肠道细菌,特别是Bacteroides和Bifidobacterium物种,相互作用影响婴儿的认知发育. 这些发现突出了影响早期学习和发展的新途径.
科学领域:
- 微生物学 微生物学
- 发展心理学 发展心理学
- 营养科学 营养科学
背景情况:
- 婴儿认知,肠道微生物群和人乳寡糖化物 (HMO) 之间建立了独立的关联.
- 关于肠道微生物群和HMO对婴儿认知发育的相互作用影响的研究有限.
研究的目的:
- 研究HMO与特定肠道细菌 (Bacteroides,Bifidobacterium) 之间的相互作用,与婴儿的认知发育有关.
- 确定这些相互作用如何影响典型发育婴儿的认知结果.
主要方法:
- 对105个母婴二合体进行纵向分析,采集母乳和婴儿便样本.
- 使用早期学习的穆伦尺度进行认知评估.
- 统计建模 (线性混合效应模型) 分析HMO水平,细菌丰富度及其相互作用,调整共变量.
主要成果:
- 细菌类物种显示与运动功能有关.
- Bifidobacterium catenulatum与LNFP-I相互作用,对可检测的A-四组的视觉接收产生负面影响.
- 在无法检测的A-tetra组中观察到显著的相互作用,各种HMO和Bifidobacterium/Bacteroides物种与不同的认知领域呈现出正面和负面的关联.
结论:
- 肠道微生物群和HMO独立而互动地与早期认知发育有关.
- 人体机体与特定肠道细菌 (Bacteroides,Bifidobacterium) 之间的相互作用呈现潜在的途径,影响婴儿的认知发育.
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