网络枢纽的断开是缺陷执行功能的基础,在患有缺血性白血病的患者中
Mengxue Wang1, Guofeng Zhao2,3, Ying Jiang4
1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.
Journal of Alzheimer's disease : JAD
|July 17, 2023
概括
缺血性白血病 (ILA) 破坏大脑连接,特别是在默认模式网络中,导致像执行功能受损等认知缺陷. 这项研究使用了自身向量中心性映射来识别ILA患者的这些网络枢纽中断.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 缺血性白血病 (ILA) 通常会导致认知障碍,但其神经生物学基础尚不清楚.
- ILA越来越多地被视为"断开综合征",其中一个混乱的大脑连接体是认知缺陷的基础.
- 了解这些干扰对于有效的ILA管理至关重要.
研究的目的:
- 在ILA患者中调查大脑网络枢纽中发生的干扰.
- 为了利用基于voxel的自向量中心性 (EC) 映射,一种新的分析方法.
- 为了将功能连接性变化与认知性能缺陷相关联.
主要方法:
- 包括中度至重度白质超强度的ILA患者 (Fazekas分数≥3) 和健康对照 (Fazekas分数=0) 的人.
- 使用静止状态功能磁共振成像 (fMRI) 和EC映射.
- 在ILA患者中分析全脑网络连接性改变.
主要成果:
- 与健康对照组相比,ILA患者在情节性记忆,处理速度和执行功能方面表现明显差.
- ILA患者在中间默认模式网络区域表现出功能连接性降低 (较低的EC值),包括后侧环状回环和腹部中间前额叶皮层 (vMPFC).
- 在右侧vMPFC的功能连接强度和ILA患者的执行功能缺陷之间发现了积极的相关性.
结论:
- 研究结果表明,在ILA患者的全脑网络中,默认模式网络区域内存在一个混乱的层次结构.
- 这项研究促进了对ILA执行功能缺陷背后的神经生物学机制的理解.
- 网络枢纽中断,特别是在默认模式网络中,与ILA相关的认知障碍有关.
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