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用于FLASH放射治疗研究的旋转阳极X射线管的剂量测量表征

Devin Miles¹, Daniel Sforza¹, John Wong¹

¹Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Medical physics

|July 17, 2023

概括

旋转的阳极X射线管可以实现超高剂量速率 (FLASH) 辐射用于临床前放射生物学研究. 这种具有成本效益的方法提供了可访问的实验室FLASH研究.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
临床前研究临床前研究

背景情况:

超高剂量率 (FLASH) 辐射研究通常需要先进的,难以接近的加速器.
千伏X射线管为基于实验室的FLASH研究提供了潜在的经济替代方案.

研究的目的:

为实验室FLASH辐射研究进行旋转阳极X射线管的综合剂量测量评估.
评估使用这项技术进行临床前放射生物学研究的可行性.

主要方法:

一个高容量的光学X射线管 (75千瓦) 被用作FLASH辐射器.
放射色膜和TLD被用来测量固体水幻体中的剂量速率和剂量深度配置文件,其处于各种源至表面距离 (SSD) 和场面大小.
定制的3D打印配件可以在短的SSD上进行可复制的幻影设置.

主要成果:

在高达10毫米的深度,在固体水中,FLASH剂量速度超过40 Gy/s.
96 Gy/s的最大表面剂量率被记录在47毫米的SSD在一个开放的领域.
在5毫米深处,合并光束表现出合理的均性,半阴影<1毫米.
升级时间不到1 ms.

结论:

旋转阳极X射线管技术是产生临床前FLASH辐射束的可行选择.
这种方法提高了基于实验室的FLASH放射生物学研究的可访问性.

关键词:

闪光照射疗法闪光照射疗法剂量测量方法剂量测量方法小动物辐射器辐射器

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