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了解急性和长期COVID使用大脑器官的神经学影响
Laura García-González1,2,3, Andrea Martí-Sarrias1, Maria C Puertas4,5,6
1Institute of Neurosciences, Department of Pathology and Experimental Therapeutics, Medical School, Universitat de Barcelona, L'Hospitalet de Llobregat 08907, Spain.
Disease models & mechanisms
|July 17, 2023
概括
长期COVID是SARS-CoV-2感染后的一种持续性疾病,导致各种神经问题. 大脑器官模型有助于了解这种疾病的神经病理学.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 关于COVID-19的长期影响的担忧在流行病的早期出现.
- 感染SARS-CoV-2可以导致持续数月或数年的慢性神经系统疾病,称为长期COVID.
- 长期COVID呈现出各种神经症状,从轻度到重度.
结论:
- 大脑器官是研究长期COVID病理生理学的宝贵工具.
- 使用这些模型进行进一步的研究可以阐明COVID-19相关神经系统疾病背后的机制.
- 了解神经病理学对于管理长期COVID至关重要.
相关概念视频
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
Neuroplasticity
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

