儿童和青少年细胞癌的生存相关因素:一个基于人口的研究
Lingling Zhao1, Wenyuan Liu2, Likai Chu3
1Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
ANZ journal of surgery
|July 17, 2023
概括
儿科细胞癌 (RCC) 的预后取决于种族,SEER阶段和手术类型. 白人患者和局部瘤患者在这个基于人口的研究中生存率更高.
科学领域:
- 儿科瘤学 儿科瘤学
- 流行病学 流行病学
- 癌症预后 癌症预后
背景情况:
- 细胞癌 (RCC) 在儿童和青少年中很少见.
- 了解预后因素对于改善儿科RCC的结果至关重要.
- 基于人口的研究为疾病模式和生存提供了宝贵的见解.
研究的目的:
- 在儿科和青少年群体中确定细胞癌 (RCC) 的预后.
- 确定影响年轻RCC患者生存的人口和临床因素.
- 为儿科瘤学中的临床决策提供流行病学证据.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 计划 (2000-2018) 中对儿科RCC患者的回顾性分析.
- 卡普兰-梅尔估计和日志等级测试用于生存曲线分析.
- 考克斯比例危险回归确定了与整体存活率相关的因素.
主要成果:
- 在251名儿科RCC患者中,3年和5年的整体存活率分别为93.5%和92.0%.
- 多变量分析确定了性别,种族,组织学类型,SEER阶段,AJCC阶段和手术类型作为独立的预后因素.
- 与黑人患者相比,白人患者的死亡风险较低 (HR 2.58). 与局部瘤相比,转移性疾病显著增加死亡风险 (HR 43).
结论:
- 种族,SEER阶段和手术方法是儿科RCC的关键预后指标.
- 这些发现强调了在治疗儿科脏瘤方面需要种族/种族特异性的策略.
- 这些流行病学数据支持儿童RCC的基于证据的临床实践.
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