性激素的变化及其相互作用与不同月经子阶段之间的疼痛感知有关
Luyao Zhang1, Ying Zhao1, Xinmin Liu1
1Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
概括
孕激素和雌激素等性激素会影响女性对疼痛的感知. 月经周期期间疼痛值的变化与荷尔蒙波动有关,特别是压力疼痛.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 疼痛研究 疼痛研究
背景情况:
- 性激素和整个月经周期的疼痛感知之间的关系仍然不完全理解.
- 调查这些荷尔蒙影响对于了解女性疼痛的变化至关重要.
研究的目的:
- 检查不同月经周期子阶段的健康年轻女性实验性疼痛感知的变化.
- 探索性激素,包括益生素,孕和雌激素在调节疼痛敏感性的特定作用.
主要方法:
- 66名健康的年轻女性参与者在月经周期的早期到中期的卵泡 (emF) 和中期的乳液 (mL) 亚阶段进行了评估.
- 测试了多种疼痛模式,包括压力疼痛,感冒疼痛,缺血性疼痛和针头疼痛.
- 激素水平 (益生素,孕激素,雌激素) 与疼痛评估同时进行测量.
主要成果:
- 与右骨早期到中期的卵泡期相比,在中期的形期观察到压力疼痛值的显著降低.
- 压力疼痛值和耐受性的变化与益生素,孕和雌激素水平的绝对和相对变化相关.
- 雌激醇和孕激素之间的相互作用显著影响了压力疼痛耐受性,特别是在特定的荷尔蒙值时.
结论:
- 疼痛感知,特别是压力疼痛敏感性,在健康的年轻女性的月经周期中可能会有所不同.
- 性激素,特别是孕激素和雌激素,在调节疼痛感知方面发挥作用,观察到相互作用作用.
- 需要进一步的研究来充分阐明荷尔蒙波动和整个月经周期的疼痛敏感性之间的复杂相互作用.
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