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Updated: Jul 23, 2025

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

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Published on: January 25, 2017

衰老信号诱导纳米颗粒刺激巨介导编程去除炎性中性粒细胞

Kaige Chen^1,2,3, Zheng Zhang⁴, Ziyuan Fang³

¹Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.

|July 17, 2023

概括

这项研究引入了PC@PLGA纳米颗粒,模仿衰老信号,触发过早清除活性中性粒细胞,减少急性肺损伤和胰腺炎模型中的炎症和组织损伤.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

中性质性炎症会导致显著的组织损伤.
亡通常会清除激活的中性粒细胞,但在异常炎症中会受到损害.
外源性calreticulin作为一个"衰老"信号,触发巨细胞中介编程细胞去除 (PrCR),独立于亡.

研究的目的:

开发一种纳米介导的策略,使用人工老化信号精确清除激活中性粒细胞.
缓解炎症并防止与中性友炎症相关的组织损伤.

主要方法:

制造PC@PLGA纳米颗粒使用由血小板衍生的细胞外囊泡 (PEVs) 和calreticulin表达膜覆盖的聚乳-co-glycolic酸 (PLGA).
利用PEV中的P-选择因用于激活中性粒细胞向.
使用calreticulin模仿衰老信号并启动巨细胞介导的PrCR.

主要成果:

PC@PLGA纳米粒子专门针对活性中性粒细胞.
巨细胞被诱导识别向的中性粒细胞为"老",启动过早的PrCR.
这一过程防止了促炎反应,并减少了急性肺损伤和严重急性胰腺炎的小鼠模型中的组织损伤.

结论:

使用外源老化信号向消除活性中性粒细胞是炎症治疗的有效策略.
PC@PLGA纳米颗粒通过促进有效的中性粒细胞清除,显示出治疗炎症的潜力.

关键词:

生物模拟纳米颗粒生物模拟纳米颗粒激活的中性粒细胞.年龄的信号信号.炎症治疗治疗炎症有计划的细胞去除.

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