相关实验视频

Updated: Jul 23, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

功能性核酸工程生物条形码纳米平台,用于针对性协同治疗多药耐药癌症

Shuangcheng Zhi¹, Xiaoyue Zhang², Jian Zhang²

¹College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

|July 17, 2023

概括

这项研究开发了一种使用功能性核酸 (FNA) 和生物条形码 (BBC) 概念的新型纳米平台,用于对抗多药耐药 (MDR) 癌症. 纳米医学触发铁和基因疗法,有效地逆转癌症药物耐药性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

多抗药性 (MDR) 癌症构成了重大的治疗挑战.
开发多功能纳米药物对于提高癌症治疗疗效至关重要.
功能性核酸 (FNA) 提供了针对药物输送和治疗的多功能平台.

研究的目的:

根据生物条形码 (BBC) 概念构建FNA设计的纳米平台,用于MDR癌症的协同向治疗.
通过联合化疗,基因疗法和铁灭诱导来研究纳米平台逆转癌症MDR的能力.
评估纳米平台在MDR人类肺腺癌细胞中的有效性 (A549/DDP).

主要方法:

合成了一种 (IV) 前药物,与FNAs联,以创建类似BBC的DNA纳米.
封装的氧化 (ZnO) 纳米粒子 (NP) 通过静电相互作用在纳米层内.
用AS1411的阿巴特马来进行特定的细胞吸收,并触发细胞内药物/DNA酶释放,以应对瘤微环境 (酸性pH,GSH).

主要成果:

该纳米平台成功地将Pt(IV) 前药物和ZnONP输入A549/DDP细胞.
ZnO NPs的细胞内降解产生了活性氧物种 (ROS),并通过GSH释放的活性Pt (II) 和治疗性DNA酶减少了Pt (IV).
该系统通过耗尽GSH和降低GPX4的调节来诱导铁,放大氧化应激,并通过沉默EGR-1mRNA来抑制MDR细胞增殖/迁移,从而克服P-gp介导的药物流量.

结论:

设计的纳米平台通过重塑细胞内环境,展示了用于协同癌症治疗的有希望的策略.
这种方法通过联合治疗机制有效地逆转肺腺癌细胞中的MDR.
这项研究强调了FNA工程纳米药物在开发MDR癌症多功能和个性化治疗的潜力.

关键词:

DNA纳米技术 DNA纳米技术功能性核酸的功能性核酸多重耐药性癌症多种药物耐药性癌症多模式疗法多模式疗法瘤微环境是一个微环境.

更多相关视频

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Published on: June 18, 2013

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...