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来自英国生物银行数据库的人群中,萨科佩尼亚和骨折风险之间的关联
Charlotte Jauffret1, Renaud Périchon2, Antoine Lamer2
1Rheumatology Department, University of Lille, CHU Lille, ULR 4490 - MABLab, Lille, France.
概括
在中年成年人中,前性和性显著增加骨折风险. 这项研究发现,肌肉强度或质量较低的个体中骨折和严重骨质疏松性骨折的发生率更高.
科学领域:
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
- 骨健康 骨健康 骨健康
背景情况:
- 关于患有前缩症和缩症的个体的骨折风险存在相互矛盾的发现.
- 标志着肌肉损失的萨尔科佩尼亚是老龄化人口日益关注的问题.
- 了解肌肉健康和骨折风险之间的关系对于预防策略至关重要.
研究的目的:
- 为了研究前症,前症和骨折风险之间的联系.
- 为了确定肌肉强度 (手握强度) 和/或质量 (骨肌指数) 的降低是否预测未来的骨折事件.
- 分析中年人群中大量的骨折风险,使用已确立的肉症标准.
主要方法:
- 使用英国生物库数据集进行的回顾性队列研究.
- 应用欧洲老年人肉症工作组2 (EWGSOP2) 定义准肉症和肉症的标准.
- 通过手握力 (HGS) 评估肌肉力量,通过骨肌肉指数 (SMI) 评估肌肉质量.
- 骨折事件,包括主要骨质疏松性骨折 (MOF),使用Cox比例危险模型识别和分析.
主要成果:
- 总共有387,025名参与者被分析,随访时间中位数为12年.
- 宫前 (仅低HGS或仅低SMI) 和宫前的参与者显示整体骨折的风险明显更高.
- 骨折的调整危险比率 (HRa) 为1.26 (前copenia小组1),1.20 (前copenia小组2) 和1.30 (sarcopenia).
- 在sarcopenic和sarcopenic组中,也观察到主要骨质疏松性骨折 (MOF) 的风险增加.
结论:
- 在中年人群中,前和是骨折 (包括MOF) 的重要危险因素.
- 这些发现凸显了评估骨折风险预测中的肌肉健康的重要性.
- 早期识别和干预肉类可能有助于减少骨折发生率.
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