动脉硬是否会预测患有硬化硬化症的患者的死亡率:长期随访研究
A Çolak1, M E Özpelit, M Birlik
1Department of Cardiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. aysecolak1@windowslive.com.
European review for medical and pharmacological sciences
|July 17, 2023
概括
动脉硬度参数没有预测系统性硬化症 (SSc) 患者在十年内死亡率. 升高的C-反应蛋白 (CRP) 成为这一队列中所有原因死亡率的关键预测因素.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 临床研究 临床研究
背景情况:
- 系统性硬化症 (SSc) 与亚临床宏大血管功能障碍有关.
- 动脉硬度 (AS) 参数用于评估血管健康.
- 在SSc临床结果中AS的预后意义仍然未得到充分研究.
研究的目的:
- 调查AS参数在预测SSc患者全因死亡率中的预后价值.
- 评估心血管辐射脉冲波速率 (PWV) 和增强指数 (AIx) 是否可以预测SSc中的生存率.
主要方法:
- 测量AS参数 (PWV和AIx) 使用平面化度计.
- 包括60名SSc患者没有肺动脉高血压或显著的心脏参与.
- 进行了平均10.3年的随访,以评估死亡率.
主要成果:
- 在随访期间,总死亡率为29.4%.
- 死亡率的重要预测因素包括肺部感染,一氧化碳扩散能力降低,估计较低的淋巴膜过率和C反应蛋白 (CRP) 的升高.
- 升高的CRP是所有原因死亡率的独立预测因素;AS参数 (AIx和PWV) 与死亡率无关.
结论:
- 动脉硬度参数似乎没有预后价值,对于SSc患者的全因死亡率.
- 需要进一步的大规模研究来阐明SSc中心血管死亡的机制,特别是关于动脉样硬化的起源.
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