在重症监护室治疗的COVID-19患者中,DNA损伤和氧化生物分子的变化:一个单一中心的经验
E Duran1, S Taşkın, B Pehlivan
1Department of Anesthesiology and Reanimation, Medicine Faculty, University of Harran, Sanliurfa, Turkey. dreduran@harran.edu.tr.
European review for medical and pharmacological sciences
|July 17, 2023
概括
血清中马隆迪甲基 (MDA) 和蛋白碳基 (PC) 水平,以及DNA损伤,可以帮助预测COVID-19患者的死亡率. 在重症监护室 (ICU) 监测这些生物标志物可以改善预后决策并减少死亡.
科学领域:
- 生物化学 生化学
- 分子生物学分子生物学
- 关键护理医学 关键护理医学
背景情况:
- COVID-19带来了显著的死亡风险.
- 了解预后标志物对于患者管理至关重要.
- 氧化应激和DNA损伤与严重的COVID-19有关.
研究的目的:
- 为了研究血清中马隆迪甲 (MDA) 和蛋白质碳 (PC) 和DNA损伤水平作为COVID-19预后的潜在生物标志物.
- 评估这些标志物与重症监护室 (ICU) 患者的死亡率之间的相关性.
主要方法:
- 在COVID-19患者的血清MDA,PC水平和DNA损伤的比较,按生存状态分组.
- 在ICU入院后的1,3,5天进行的测量.
主要成果:
- 在非幸存者中,MDA随着时间的推移而增加,PC在第3天达到峰值,DNA损伤逐渐增加.
- 在幸存者中,MDA随着时间的推移而下降,PC在第1天达到峰值,DNA损伤显示出最初的下降,随后的最小增加.
结论:
- 血清MDA,PC水平和DNA损伤是预测COVID-19ICU患者死亡率的潜在生物标志物.
- 这些标记可以帮助做出预后决策.
- 利用这些生物标志物可能有助于降低COVID-19死亡率.
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