站立血压和跌倒的风险,昏迷,冠心病和死亡率
Jordan K Kondo1, William B Earle2, Ruth-Alma N Turkson-Ocran1,2
1Harvard Medical School, Boston, Massachusetts, USA.
American journal of hypertension
|July 17, 2023
概括
低静止系统性血压 (SBP) 是常见的,与跌倒或昏迷无关. 然而,它与降低成人冠心病 (CHD) 和死亡率的风险有关.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 目前的ACC/AHA指南建议小心使用抗高血压药物治疗低静脉压 (SBP) <110毫米升,因为益处不确定.
- 低SBP是临床实践中常见的发现,促使对其临床意义进行调查.
研究的目的:
- 为了调查低站的SBP (<110毫米平) 与不良结果的风险之间的联系.
- 评估低站SBP和跌倒,昏迷,冠心病 (CHD) 和死亡率之间的关系.
主要方法:
- 利用了来自社区动脉样硬化风险研究 (ARIC) 的数据,测量了45-64岁成年人的SBP (1987-1989).
- 采用考克斯回归来分析低等级SBP与结果之间的关联,并追踪到2019年12月31日.
- 通过索赔数据确定跌倒和昏迷;判决的CHD事件. 分析了不同的人口和临床层面的关联.
主要成果:
- 在12,467名参与者中,24%的人站立时SBP<110毫米.
- 低站的SBP并没有显着增加跌倒或昏睡的风险 (HRs1.02,1.02).
- 较低的SBP与显著降低心脏病事件 (HR 0.88) 和死亡率 (HR 0.91) 的风险相关.
结论:
- 低站的SBP在社区中普遍存在,并不是导致跌倒或昏迷的重要危险因素.
- 低站的SBP与降低冠心病和死亡率的风险有关.
- 结果不支持低血压的查作为不良事件的预测指标.
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