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来自中国献血者的不同组件中的病毒转基因组学的完整注释,使用下一代测序
Jingjing Zhang1,2, Yanmin He1,2, Ji He1,2
1Blood Center of Zhejiang Province, Hangzhou, China.
Blood transfusion = Trasfusione del sangue
|July 17, 2023
概括
病毒DNA存在于健康的献血者体内,在血中发现的度高于皮或血小板成分. 这一发现影响了输血安全和理解病毒分布.
科学领域:
- 病毒学 病毒学
- 输血医学 输血医学
- 基因组学就是基因组学.
背景情况:
- 捐献者血液中的新兴病毒对输血安全构成重大风险.
- 关于不同血液成分和捐献者的病毒特征的了解有限.
研究的目的:
- 调查来自中国捐献者的各种血液成分中的病毒转基因组学.
- 分析全血和非性血小板捐献者的病毒分布和特征.
主要方法:
- 用下一代测序来分析病毒转基因组学.
- 样本包括布菲外套 (BC),血和血小板 (PLT) 组件.
- 献血者包括32名全血献血者和30名非血小板献血者.
主要成果:
- 在全血献血者血和BC中检测到56种病毒;血显示出更高的病毒丰度和多样性.
- 20个病毒被发现在阿菲雷斯捐赠者的PLT和BC中;PLT的病毒载量更高.
- 与BC.相比,等离子体呈现出明显不同的病毒社区结构.
结论:
- 病毒核酸在健康的中国献血者中普遍存在.
- 血含有最高度的病毒,影响病毒分布模式.
- 这些发现对于评估输血安全性和病毒流行病学至关重要.
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