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Updated: Jul 23, 2025

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[¹⁸F]FNDP PET神经成像测试重复测试可重复性和全身剂量测量在人类

Yong Du¹, Jennifer M Coughlin², Alireza Amindarolzarbi¹

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

European journal of nuclear medicine and molecular imaging

|July 17, 2023

概括

射线追踪器[18F]FNDP显示出非常好的测试-重复测试可重复性,用于脑中可溶性环氧化酶 (sEH) 的成像. 来自[18F]FNDP PET扫描的辐射暴露与其他基于18F的标记物相美.

科学领域:

神经成像是一种神经成像.
放射化学放射化学是指辐射化学.
药理学药理学是指药理学的学科.

背景情况:

溶性环氧化酶 (sEH) 是一种调节免疫反应并维持脂肪酸平衡的关键酶.
放射追踪器[18F]FNDP使得正子发射断层扫描 (PET) 能够对大脑中的sEH进行成像.

研究的目的:

评估[18F]FNDP脑PET结合在健康个体中的测试-重复测试可重复性.
在健康个体中确定[18F]FNDP的全身剂量.

主要方法:

七名健康成年人在14天内接受了两次[18F]FNDP脑部PET扫描,以评估测试-重新测试的可变性.
区域总分布体积 (V_T) 使用代谢物校正的动脉输入函数计算.
六名健康成年人在4.5小时内接受[18F]FNDP PET/CT全身剂量测试.

主要成果:

区域V_T的平均测试-重新测试差异为0.82 ± 5.17%,类内相关系数 (ICC) 从0.92到0.99.
最高的器官吸收剂量是到胆囊 (0.081 ± 0.024 mSv/MBq),肝脏 (0.077 ± 0.018 mSv/MBq) 和脏 (0.063 ± 0.006 mSv/MBq).
据估计,有效剂量为0.020 ± 0.003 mSv/MBq.

结论:

[18F]FNDP证明了有利的测试-重复测试可重复性,用于使用PET量化大脑中的sEH.
与[18F]FNDP PET扫描相关的辐射剂量与其他基于18F的辐射追踪剂可比,支持其临床实用性.

关键词:

剂量测量方法剂量测量方法定子发射断层扫描 (PET) 是一种定子发射断层扫描.可重复性可重复性这就是SEHH.

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