使用电子尼古丁输送系统与尼古丁皮肤贴片相结合,减少吸烟
Jed E Rose1, Suzanne Frisbee2, David Campbell2
1Duke Center for Smoking Cessation, Duke University School of Medicine, 2424 Erwin Road, Suite 201, Durham, NC, 27705, USA. jed.rose@duke.edu.
使用尼古丁的电子尼古丁输送系统 (ENDS) 显著减少了吸烟,通过一氧化碳水平来衡量. 在这项研究中,尼古丁皮肤贴片对吸烟减少没有显著影响.
科学领域:
- 烟草控制研究 烟草控制研究
- 尼古丁成研究的研究.
- 行为健康干预措施 行为健康干预
背景情况:
- 吸烟者使用电子尼古丁输送系统 (ENDS) 来减少可燃香烟 (CC) 的使用.
- 尼古丁替代剂与行为/感官因素在ENDS疗效中的具体作用尚不清楚.
- 这项研究调查了通过ENDS和贴片输送尼古丁对减少吸烟的影响.
研究的目的:
- 与安慰剂相比,评估含有尼古丁的ENDS的效果 ENDS.
- 为了评估尼古丁贴片与安慰剂贴片相比,尼古丁贴片的影响.
- 为了确定对减少吸烟行为的综合影响.
主要方法:
- 94名每日吸烟者被随机分为四组:尼古丁ENDS/尼古丁贴片,尼古丁ENDS/安慰剂贴片,安慰剂ENDS/尼古丁贴片和安慰剂ENDS/安慰剂贴片.
- 在8周的时间内,使用自我报告和过期空气一氧化碳 (CO) 测量来评估吸烟减少.
- 主要的结果措施是减少过期空气中的CO2含量.
主要成果:
- 在ENDS中的尼古丁显著减少了吸烟, CO变化的差异与安慰剂相比减少了9.2ppm.
- 过期CO的减少与自我报告的每日香烟消费量下降有很强的相关性 (r=0.6).
- 尼古丁贴片对吸烟减少没有统计学上显著的影响 (CO变化差异 = -0.1 ppm).
结论:
- 通过ENDS输送尼古丁与大幅减少吸烟密切相关.
- 需要进行进一步的研究,以探索将尼古丁ENDS与尼古丁贴片结合用于戒烟的潜在附加益处.
- 这些发现强调了ENDS中尼古丁含量的重要性,以减少可燃香烟的使用.
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