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甲类药物可以降低骨科创伤患者的外科手术期间的阿片类药物需求吗? 一个单一中心的回顾性分析分析
Pragadeeshwaran Jaisankar1, Bhaskar Sarkar1, Nirvin Paul1
1Department of Trauma Surgery, AIIMS Rishikesh, Uttarakhand, 249203, India.
概括
在四肢骨折手术中使用 gabapentin 显著降低了与单独服用青相比,对阿片类止痛药的需求. 这项研究强调了 gabapentin 作为一种有价值的非阿片类药物选择,用于骨科创伤中的术后疼痛管理.
科学领域:
- 整形外科手术 整形外科手术
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨科创伤/四肢骨折的术后疼痛控制是一个重大的临床挑战.
- 加巴类药物越来越多地被探索为各种骨科子专业的非阿片类药物辅助剂.
- 研究 gabapentin 在四肢骨折的外科手术期疼痛管理中的疗效是有必要的.
研究的目的:
- 评估加巴丁与降醇联合用于手术前疼痛控制在接受手术固定的四肢骨折患者的有效性.
- 为了比较接受 gabapentin 和青与单独服用青的患者之间的阿片类止痛药需求和疼痛评分.
主要方法:
- 对119名患有孤立长骨四肢骨折的患者进行了回顾性比较研究.
- 患者被分为两组: gabapentin + 降醇 (GP) 和非 gabapentin + 降醇 (NGP).
- 加巴丁在术前和术后使用;通过VAS得分和额外的阿片类药物使用来评估疼痛.
主要成果:
- 与NGP组 (74%) 相比,GP组 (41%) 的阿片类止痛药需求明显较低 (p < 0.01).
- 在所有测量时间点上,两组之间的VAS分数没有显著差异.
- 在NGP组的关节内骨折显示了显著更高的阿片类药物需求.
结论:
- 补充甲巴丁与白醇有效地减少了四肢骨折患者的外科期阿片类药物消耗.
- gabapentinoids 为减轻创伤手术疼痛管理中的阿片类药物相关并发症提供了一种可行的策略.
- 建议对肢体创伤的标准化疼痛管理指南进行进一步的研究.
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