在加利福尼亚州,按年龄组分类的逆侧继发性乳腺癌后的生存率
Lauren M Perry1, Theresa H M Keegan2,3,4, Qian Li2
1Division of Surgical Oncology, Department of Surgery, University of California Davis School of Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA.
Annals of surgical oncology
|July 17, 2023
概括
反侧继发性乳腺癌 (CSBC) 幸存者比原发性乳腺癌 (pBC) 患者的生存率更差,尤其是年轻女性. 这表明需要重新考虑CSBC治疗策略,尽管瘤具有有利的特征.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 乳腺癌 (BC) 是最常见的二次恶性瘤.
- 逆侧二次乳腺癌 (CSBC) 是BC幸存者中最常见的第二种癌症.
- 目前对CSBC的治疗与初级BC (pBC) 的治疗相似.
研究的目的:
- 为了比较CSBC和pBC之间的生存结果.
- 确定CSBC患者治疗或咨询方面的潜在差异.
主要方法:
- 来自加利福尼亚癌症注册 (1991-2015) 的377,176例pBC病例和15586例CSBC病例的分析.
- 根据年龄组分层的比较:15-39岁,40-64岁和≥65岁.
- 用于评估因素和BC特定生存率 (BCSS) 的多变量后勤和Cox比例危险回归模型.
主要成果:
- 跨越所有年龄段的CSBC患者更有可能患有较小的瘤和淋巴结阴性疾病.
- 尽管瘤特征有利,但CSBC与pBC相比的生存率明显差.
- 生存差异在年轻女性 (15-39岁) 中最为明显.
结论:
- 被诊断为CSBC的女性表现出比pBC的女性更糟糕的BCSS.
- 这些发现表明,CSBC可能需要不同的治疗考虑,特别是在年轻人群中.
- 对CSBC特定管理的进一步研究是有必要的.
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