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基于干细胞的视网膜色素上皮质替代疗法的进展:在体外分化到体外分娩
Santosh Gupta1, Lyubomyr Lytvynchuk2,3, Taras Ardan4
1Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Stem cells translational medicine
|July 17, 2023
概括
多能干细胞衍生的视网膜色素表皮质 (pRPE) 为视网膜疾病,如与年龄相关的黄斑变性 (AMD) 提供了有前途的再生疗法. 本综述涵盖了pRPE衍生,移植以及开发功能性RPE组织的挑战.
科学领域:
- 眼科和再生医学眼科和再生医学
- 干细胞生物学和组织工程
背景情况:
- 视网膜色素表皮 (RPE) 对于视力至关重要,形成血视网膜屏障并支持光受体.
- RPE功能障碍和损失与退行性疾病有关,例如与年龄相关的黄斑退行 (AMD).
- 多能干细胞衍生的RPE (pRPE) 为RPE相关疾病提供了潜在的再生治疗策略.
研究的目的:
- 审查目前从多能干细胞获得RPE的策略.
- 讨论将pRPE输入子内空间以进行移植的方法.
- 突出最近的临床研究和基于pRPE的视网膜疾病治疗的挑战.
主要方法:
- 关于基于干细胞的RPE衍生和移植的科学文献的综述.
- 对体外RPE培养和成熟策略的分析.
- 对pRPE移植的临床试验数据的检查.
主要成果:
- pRPE衍生需要特定的血统分化和扩展的体外培养以成熟.
- 基于pRPE的移植的子视网膜输送是一个活跃的研究领域.
- 最近的临床研究正在探索pRPE移植在AMD患者的安全性和有效性.
结论:
- 了解RPE分化是成功基于干细胞的RPE衍生的关键.
- 克服体外RPE培养的局限性对于开发用于移植的功能性RPE组织至关重要.
- pRPE移植对治疗与RPE相关的视网膜退化有前途,目前正在进行临床研究.
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