行为和临床风险因素与白内障的关联:一个双样本的孟德尔随机化研究
Chen Jiang1, Ronald B Melles2, Poorab Sangani3
1Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, California, United States.
Investigative ophthalmology & visual science
|July 17, 2023
概括
基因决定的原发性开放角光眼 (POAG) 和近视会增加与年龄相关的白内障风险. 其他因素,如2型糖尿病和BMI没有显著关联,这表明POAG和近视是白内障的因果风险因素.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 与年龄相关的白内障是全球视力障碍的主要原因.
- 了解白内障的遗传和环境风险因素对于制定有效的预防和查策略至关重要.
- 以前的研究表明,各种临床和行为因素与白内障风险之间存在关联,但因果关系尚不清楚.
研究的目的:
- 调查遗传决定的初级开角青光眼 (POAG),近视折射误差 (RE),2型糖尿病 (T2D),血压 (BP),体重指数 (BMI),吸烟和饮酒与与年龄相关的白内障风险的关联.
- 评估这些因素对白内障风险的潜在因果影响,使用双样本门德尔随机化方法.
主要方法:
- 利用两样本的孟德尔随机化分析,使用来自全基因组关联研究 (GWAS) 的遗传仪器.
- 来自大型GWAS队列 (GERA和英国生物库) 的就业总结统计数据,用于与年龄有关的白内障.
- 应用逆变量加权 (IVW) 方法作为主要分析,并进行灵敏度分析以确认发现.
主要成果:
- 基因决定的POAG与与年龄相关的白内障风险增加显著相关 (OR = 1.04).
- 近视折射误差 (RE) 与白内障风险降低有显著的关联 (OR = 0.92 每二眼镜更高视度).
- 基因决定的T2D,BP,BMI,吸烟和酒精消费与白内障风险没有显著关联.
结论:
- 对POAG和近视的遗传倾向可能是与年龄相关的白内障的因果风险因素.
- 这些发现支持先前的观察性研究,该研究将近视与白内障风险联系起来.
- 这些见解可以为基于人口的白内障风险分层和查策略提供信息.
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