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在以前未经治疗的高级固体瘤中进行一线基因组分析,以确定向治疗机会

Junichi Matsubara¹, Kumi Mukai¹, Tomohiro Kondo¹

¹Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.

JAMA network open

|July 17, 2023

概括

在标准护理治疗之前的综合基因组分析 (CGP) 在100%的晚期固体瘤患者中发现了可操作的改变. 这种精确的瘤学方法可以指导随后的分子匹配疗法,证明临床实用性.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
精准医学是一门精准的医学.

背景情况:

精密瘤学利用综合基因组分析 (CGP) 进行伴随性诊断和基因组表征.
在高级固体瘤中,CGP在标准护理 (SOC) 之前的临床实用性需要进一步的证据.

研究的目的:

调查下一代CGP (FoundationOne CDx) 在以前没有接受过治疗的患有转移性或复发性固体瘤的患者的临床效用.
评估可采取行动或可药物治疗的基因组变异患者的比例,并确定基于分子的推疗法 (MBRT).

主要方法:

一项多中心,前性,观察性队列研究,涉及180名在日本6家医院之前未经治疗的高级固体瘤患者.
患者在SOC之前接受了CGP测试,结果分析了可采取行动/可药物改变和MBRT.
进行了随访,以评估基于CGP结果的治疗决定.

主要成果:

在100%的患者 (n=172) 中发现了可操作的基因组变化.
在63.4%的患者中发现了可用药物的改变,并建议MBRT用于61.0%的患者.
在分析的172名患者中,19.8%的患者在平均7.9个月的随访后接受了MBRT.

结论:

在先进的固体瘤中,在SOC之前的CGP测试在所有患者中发现了可操作的变化.
这种方法可以通过指导随后的抗癌疗法,包括分子匹配治疗,提供临床益处.
进一步的证据支持CGP在精密瘤学中对先前未经治疗的先进固体瘤的有用性.

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