使用不同间接技术对参考区间计算的影响:观察性研究
Dan Yang1, Zihan Su1, Runqing Mu1
1National Clinical Research Center for Laboratory Medicine, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Journal of medical Internet research
|July 17, 2023
概括
建立参考区间 (RIs) 的间接方法显著影响结果,像Tukey和代平均值 (3SD) 这样的异常移除方法显示了类似的效率. 间接技术的选择取决于分析物的特性,为使用现有数据的临床实验室提供证据.
科学领域:
- 临床实验室科学 临床实验室科学
- 生物统计学 生物统计学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 参考间隔对于临床决策至关重要.
- 直接确定RI是昂贵且耗时的.
- 使用现有实验室数据的间接方法正在获得引力.
研究的目的:
- 评估各种间接方法的准确性,以建立完整血清 (CBC) 参考间隔 (RIs).
- 评估数据转换和异常值去除技术对 RI 准确性的影响.
- 将间接方法的结果与直接方法标准进行比较.
主要方法:
- 利用来自成人体检 (2010-2011) 的大规模CBC数据.
- 应用了多种间接方法 (例如,参数,非参数,霍夫曼,巴塔查利亚,宇宙) 与日志/BoxCox转换.
- 采用了异常值去除技术 (里德-迪克森,图基,代平均值 (3SD)) 和计算偏差比率 (BR).
主要成果:
- 数据的转换和异常值的删除显著影响了RI,特别是偏差数据.
- 图基和代平均值 (3SD) 方法显示了可比的异常值去除效率.
- 间接方法的性能因分析物和性别而异;Bhattacharya,霍夫曼和参数方法在男性的某些CBC参数方面优越.
结论:
- 异常值清除和间接技术显著影响最终的RI;数据转换的影响最小,除非数据高度歪曲.
- 最优的间接技术是依赖于分析物.
- 这项研究提供了支持临床实验室使用历史数据建立RI的证据.
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