口服后生物作为治疗性皮肤炎的治疗策略:对随机对照试验的系统审查
Madalena Lima1, Luciana Campos Paulino1
1Center for Natural Sciences and Humanities, Federal University of ABC, Santo André-SP, Brazil.
Journal of the American Nutrition Association
|July 17, 2023
概括
口服Lactobacillus后生菌在成人亚托皮性皮炎 (AD) 症状管理方面表现有前途. 然而,目前的证据不支持它们在患有AD的儿科患者中的有效性.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 亚托皮炎 (AD) 是一种广泛的慢性皮肤疾病.
- 肠道微生物组在阿尔茨海默病中的作用导致探索口服益生菌.
- 非活性的后生菌为AD管理提供了一个比益生菌更安全的替代品.
研究的目的:
- 评估口服Lactobacillus后生菌在治疗AD症状中的有效性.
- 为了评估儿童和成人患者群体的疗效.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 包括9个随机对照试验 (RCT),涉及512名参与者.
- 对给非活性的Lactobacillus spp.的研究进行分析. 口服给阿兹海默症患者.
主要成果:
- 成年患者在接受 Lactobacillus 后生物的治疗后,症状有所改善.
- 儿科患者从后生物治疗中并没有始终显示出积极的结果.
- 剂量和与可活益生菌的比较影响了结果;轻微的不良反应很少见.
结论:
- 乳酸菌后生物可以作为成人AD的有效辅助疗法.
- 目前没有足够的证据来推治疗儿科阿尔茨海默病的后生物药物.
- 需要使用标准化方法和更广泛的人群进行进一步的研究,以澄清后生物效应和微生物组影响.
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