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含有氧化的树脂内牙密封剂的生物研究

Carlos Roberto Emerenciano Bueno¹, Francine Benetti², Marina Tolomei Sandoval Cury¹

¹Department of Preventive and Restorative Dentistry, Endodontic Section, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.

|July 17, 2023

概括

这项研究发现,氧化内牙密封剂通常具有良好的生物相容性和抗菌性质. 与其他测试的密封剂相比,Sealer 26在体内表现出优异的生物矿物化和原成熟.

科学领域:

生物材料科学生物材料科学
牙周内科医院牙周内科医院牙周内科医院
组织工程是组织工程.

背景情况:

基于氧化的内牙密封剂广泛用于根管填充.
评估它们的生物反应,包括生物相容性和生物矿物化,对于临床成功至关重要.
了解原蛋白成熟和抗菌活性,可以为材料选择和治疗结果提供信息.

研究的目的:

评估含氧化的树脂内牙密封剂的体内生物相容性,生物矿物化和原成熟.
评估这些密封剂的体外抗菌和细胞毒性.

主要方法:

在生体内对被植入密封体 (Sealer 26,Sealer Plus,Dia-ProSeal) 的老鼠进行了为期7,15,30和60天的实验.
试验室评估包括对抗Enterococcus faecalis的抗菌活性的阿格尔扩散试验 (ADT) 和使用纸细胞的细胞毒性MTT试验 (OD-21).
统计分析包括双向ANOVA,邦费罗尼校正,克鲁斯卡尔-瓦利斯和恩测试.

主要成果:

MTT测定显示,细胞增殖受到密封剂提取物的影响,除了1/8稀释的Dia-Proseal和Sealer Plus.
在体内,在第7天观察到中度炎症透,在所有组中,在第60天恢复到轻度炎症.
与Sealer Plus和Dia-ProSeal相比,Sealer 26在第60天表现出显著更大的生物矿物化和原纤维成熟.

结论:

所有测试的树脂内密封剂都在体外/体内表现出令人满意的生物相容性和对浮游生物细菌的抗菌活性.
密封剂26显示了增强的生物矿物化和原成熟,表明了改善组织整合的潜力.
进一步的研究可能会探索这些密封剂的长期影响和临床疗效.

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Factors Affecting Solubility

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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide: