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STRATEGY:用于法医科学中收集和分析短串联重复的下一代测序数据的支持系统

Nuttachai Kulthammanit¹, Tikumphorn Sathirapatya^2,3, Poonyapat Sukawutthiya^2,3

¹Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.

|July 17, 2023

概括

STRategy是一个新的网络应用程序,集成了来自下一代测序 (NGS) 的短串重复 (STR) 数据管理和分析. 这个工具通过提供一个集中的数据收集,参数计算和可视化平台来简化法医遗传分析.

科学领域:

法医遗传学和生物信息学.
基因组数据分析和管理.

背景情况:

短串联重复 (STR) 在法医科学中对于人类的身份和关系至关重要.
下一代测序 (NGS) 提供了先进的STR分析,包括单核酸多态 (SNP).
目前的工作流程缺乏用于NGS衍生的STR数据收集,管理和分析的集成平台.

研究的目的:

开发一个开源的,基于Web的应用程序,STRategy,用于全面的STR数据管理和分析.
提供一个统一的平台,解决碎片化的STR数据处理工具的低效性.
加强对STR重复结构和核酸变异的分析.

主要方法:

开发了STRategy作为一个独立的,基于Web的应用程序,具有集中数据库.
实现了数据收集,自动取证参数计算和数据可视化的功能.
基于角色的综合访问控制,用于组织内的安全数据管理.
启用了根据个人资料,位点,基因型和测试包进行搜索,以及核酸变体识别.

主要成果:

STRategy成功地整合了从NGS.STR数据管理和分析到STR.
该应用程序提供了法医参数的动态分析和STR模式的可视化.
用户可以通过各种选项高效地搜索和探索分析的STR数据.
该系统支持定制和管理参考STR重复图案.

结论:

STRategy提供了一个端到端的解决方案,用于管理和分析NGS衍生的STR数据.
该平台简化了法医遗传学调查和人口遗传学研究.
STRategy提高了STR数据工作的实验室和组织的效率和可访问性.
开源,Docker可部署的性质促进了广泛采用.

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