个人纵向遵守被忽视的热带疾病大规模药物管理计划,系统审查
Rosie Maddren1, Anna Phillips1,2, Santiago Rayment Gomez1
1Department of Infectious Disease Epidemiology, Imperial College London, Saint Mary's Campus, Norfolk Place, London, United Kingdom.
PLoS neglected tropical diseases
|July 17, 2023
概括
在控制被忽视的热带疾病 (NTDs) 方面,对大规模药物管理的遵守至关重要. 本次审查强调了对标准化定义和对参与者合规性进行更好的数据收集的需要,特别是关于年龄和性别的关联.
科学领域:
- 公共卫生 公共卫生
- 热带医学 热带医学
- 流行病学 流行病学
背景情况:
- 通过大规模药物管理 (MDA) 进行预防性化疗 (PC) 是控制五种被忽视的热带疾病 (NTD) 的关键.
- 计划的效率依赖于参与者一致的治疗坚持,以遵守 (吞治疗比例) 来衡量.
- 单独链接的纵向合规数据对于评估MDA影响至关重要,但对于NTDs很少收集.
研究的目的:
- 自2016年以来,在全球范围内检查PC-NTD的纵向合规数据.
- 确定合规性,年龄和性别之间的关联.
- 审查覆盖范围和合规性术语,并推标准化定义.
主要方法:
- 在PubMed和Web of Science的系统文献搜索 (2022年1月) 搜索英语和西班牙语文章.
- 采用PRISMA指南进行数据提取;Rayyan软件用于标题选.
- 纳入标准:>1个时间点,>100名参与者;数据分析在R.
主要成果:
- 89项研究确定了合规数据;57项是纵向研究,25项是单独链接数据.
- 年龄的增加通常与更高的系统治疗坚持相关.
- 报告指出,公布的数据很少,覆盖范围和合规性术语不一致.
结论:
- 迫切需要对覆盖范围,合规性和纵向合规性的标准化定义.
- 世卫组织应在NTD治疗指南中澄清这些术语,以提高数据的一致性.
- 进一步的研究和改进的数据收集对于有效的NTD控制计划至关重要.
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