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睡眠障碍和白质完整性在患有偶发性肌缩侧面硬化症的患者

Xin Li¹, Qi Liu¹, Tongyang Niu¹

¹Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, PR China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, 050000, PR China; Neurological Laboratory of Hebei Province, Shijiazhuang, Hebei, 050000, PR China.

|July 17, 2023

概括

睡眠障碍在偶发性肌缩侧面硬化症 (ALS) 中很常见,并且与白质完整性降低有关. 这表明ALS病理生理学可能直接导致患者的睡眠障碍.

科学领域:

神经科学是一个神经科学.
神经学神经学
睡眠医学睡眠医学

背景情况:

睡眠障碍在神经疾病中很普遍.
肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元.
睡眠障碍与ALS中白质完整性之间的关系尚不清楚.

研究的目的:

为了调查零星ALS患者的睡眠障碍特征.
探索睡眠质量与ALS白质整合之间的关联.
为了确定特定的白物质受ALS睡眠障碍影响的区域.

主要方法:

使用匹兹堡睡眠质量指数 (PSQI),爱普沃思睡眠度量表 (ESS) 和多睡眠图来评估睡眠.
将56名ALS患者分为睡眠质量差 (n=26) 和良好的 (n=30) 组.
采用扩散张力成像 (DTI) 来评估白物质完整性和多重回归分析.

主要成果:

睡眠质量差在ALS患者中明显更常见 (调整后几率比,4.26).
睡眠不足的患者表现出分数异构性降低,投射/指导纤维和右丘脑的扩散性增加.
PSQI得分与内部囊的右前肢和右丘脑中的白质完整性相关.

结论:

睡眠障碍在零星ALS中很常见,并且与白质完整性受损有关.
研究结果表明,ALS病理生理学可能直接导致睡眠障碍.
在特定区域的白质完整性受损可能是ALS患者睡眠问题的基础.

关键词:

扩散张力成像的成像方法病理生理学病理生理学睡眠障碍睡眠障碍是一种睡眠障碍.偶发性肌缩侧面硬化症 (AMS) 是一种病.白物质的完整性白物质的完整性

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