一种基于粉的聚合物的合成,表征和抗菌活性
Shreya Kanth1, Yashoda Malgar Puttaiahgowda1, Ananda Kulal2
1Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India.
Carbohydrate research
|July 17, 2023
概括
一种由粉和N-乙烯 piperazine 衍生的新型抗菌聚合物显示出对细菌和真菌的广泛疗效. 这种生物降解材料是无毒的,适用于伤口带和织应用.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 聚合物化学 聚合物化学
背景情况:
- 病房感染和抗生素耐药性的增加需要新的抗菌战略.
- 来自可再生资源的生物降解材料提供可持续的解决方案.
- 基于多糖的聚合物为抗菌应用提供了一个有希望的途径.
研究的目的:
- 从粉和N-乙烯 piperazine开发和描述一个新的抗菌聚合物.
- 评估合成聚合物的抗微生物疗效和细胞毒性.
- 探索在伤口包裹和织品中的潜在应用.
主要方法:
- 采用单合成方法制造N-乙烯-皮佩拉辛-粉聚合物 (SA-E-NPz).
- 福利埃变换红外光谱 (FTIR) 和核磁共振 (NMR) 用于表征.
- 热重力测量分析 (TGA) 和差分扫描热量测量 (DSC) 评估了热性能.
- 抗微生物活性测试针对金黄色葡萄球菌,大肠杆菌,Mycobacterium smegmatis和白菌.
- 使用人类纤维细胞细胞系评估了细胞毒性.
主要成果:
- 合成的聚合物SA-E-NPz表现出剂量依赖的抗菌活性.
- 抑制区在8-13毫米之间,最小抑制度 (MIC) <0.625毫克对所有测试的微生物.
- 该聚合物在涂在面料上时显示出抗微生物有效性.
- 细胞毒性测试证实该聚合物对人类纤维细胞细胞无毒.
结论:
- 开发的基于粉的抗微生物聚合物对一系列细菌和真菌具有显著的疗效.
- 它的无毒性和生物降解性使其成为安全和可持续的选择.
- 该聚合物有可能用于生物医学应用,如伤口带和功能性织品.
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