脆弱性不会在鼻腔状细胞癌中恶化术后的结果
Rijul S Kshirsagar1, Jacob G Eide2, Anas Qatanani3
1Department of Head and Neck Surgery, Kaiser Permanente Redwood City Medical Center, Redwood City, CA, United States of America.
American journal of otolaryngology
|July 17, 2023
概括
虚弱度指标对鼻状细胞癌 (SCC) 患者的术后结果没有显著影响. 进一步的研究可能会澄清脆弱性在治疗这种侵袭性癌症中的作用.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 鼻腔状细胞癌 (SCC) 是一种侵袭性的恶性瘤.
- 脆弱性评估对于预测治疗耐受性至关重要.
- 有限的数据存在于鼻癌患者的脆弱性.
研究的目的:
- 为了确定虚弱对鼻SCC患者术后结果的影响.
- 在鼻癌治疗的背景下评估脆弱度量.
主要方法:
- 来自两个三级医疗中心的鼻SCC外科切除病例的回顾性查询.
- 使用美国麻醉学会 (ASA) 分类,修改的5项脆弱指数 (mFI-5) 和查尔森并发症指数 (CCI) 计算脆弱性.
- 对术后结果的分析,包括并发症,再入院和停留时间 (LOS).
主要成果:
- 包括38名患者;平均年龄59.6岁.
- 在脆弱性测量 (mFI-5,CCI) 和术后并发症或再入院之间没有发现显著的关联.
- 增加的ASA分类预测了更长的逗留时间 (IRR: 1.80,95% CI: 1.16-2.83).
结论:
- 虚弱度指标显示,在鼻性SCC中,手术或医疗术后结果恶化与虚弱度指标没有关联.
- 对于鼻腔外科手术来说,脆弱性评估可能不那么重要,可能是由于侵入性最小的技术.
- 需要进一步的研究,才能充分理解脆弱性在鼻癌管理中的作用.
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