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高剪切颗粒处理过程参数对新型共加工的半孔二氧化材料特性的影响

Ana Baumgartner¹, Odon Planinšek¹

¹Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, Ljubljana 1000, Slovenia.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

|July 17, 2023

概括

这项研究优化了半孔合加工的辅助剂,用于直接压缩片. 实验设计确定了关键的颗粒化参数,以实现所需的材料特性,如高表面积和良好的流动性.

科学领域:

制药科学制药科学
材料科学材料科学材料科学

背景情况:

同处理的辅助剂为直接压缩片提供了优势.
半孔二氧化为药物加载和无形固体分散提供了很大的特定表面积.

研究的目的:

为了优化基于半孔的共同加工辅助剂.
通过实验设计,研究高剪切颗粒度参数对材料特性的影响.

主要方法:

利用实验设计 (DoE) 来研究高剪切颗粒.
各种参数:粘合剂 (异盐) 量,水量,添加水率,螺旋轮转速.
评估的反应:粒子大小,特定表面积,散密度,流动性,可压缩性,可压缩性.

主要成果:

开发了具有良好匹配和预测能力的预测模型.
对所有评估反应的粒度参数的已识别的活性影响.
实现了具有高特异面积,大颗粒大小,以及改善流量和压缩性能的优化产品.

结论:

该研究成功地优化了半孔合加工的助剂,用于直接压缩.
能源部提供了宝贵的见解,通过颗粒参数控制材料特性.
经过验证的模型证实了为制药配方量身定制辅助剂特性的能力.

关键词:

共同处理共同处理实验的设计实验的设计辅助物质辅助物质辅助物质高剪切颗粒制剂的高剪切颗粒制剂半孔的二氧化.

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