精神分裂症患者和健康对照参与者的延迟依赖性工作记忆扭曲有质量不同
Sonia Bansal1, Gi-Yeul Bae2, Benjamin M Robinson1
1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, School of Medicine, Baltimore, Maryland.
概括
精神分裂症患者 (PSZ) 的工作记忆 (WM) 显示出独特的动态. 与健康对照 (HCs) 不同,PSZ WM表示远离了之前的目标,表明了不同的记忆机制.
科学领域:
- 认知神经科学 认知神经科学
- 神经心理学 神经心理学
- 精神病学是一个精神病学.
背景情况:
- 工作记忆 (WM) 障碍在精神分裂症患者中很常见.
- 以前PSZ的量化WM赤字可能是由于非特定因素,如目标维护受损.
- 本研究调查了PSZ和健康对照 (HC) 之间的WM动态的定性差异.
研究的目的:
- 探索精神分裂症患者 (PSZ) 和健康对照者 (HCs) 之间工作记忆 (WM) 动态的定性差异.
- 测试这样的假设,即WM表征在HC中偏向以前的试验目标,但在PSZ中远离它们.
- 调查序列依赖在PSZ和HC之间的WM差异中的作用.
主要方法:
- 在PSZ (n=31) 和HC (n=25) 中使用空间定向延迟响应任务评估序列依赖.
- 参与者在0到8秒的延迟时间内记住了对象定向.
- 分析了当前试验记忆表示相对于以前试验目标的漂移.
主要成果:
- 与HC相比,PSZ的记忆表示在PSZ中不那么精确.
- HCs表现出代表性的吸引力,WM向前试验的方向漂移.
- PSZ表现出代表性排斥,WM偏离了前一个试验的方向.
结论:
- 显示了PSZ和HC之间的WM动态的定性差异,并不是由烦因素解释的.
- 这些发现挑战了仅依靠持续神经激活来维护信息的计算模型.
- 建议在长期,交叉试验记忆机制中存在根本的差异,例如PSZ和HC之间的强化和适应.
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