由Bifidobacterium pseudolongum产生的酸抑制了与非酒精性脂肪肝疾病相关的肝细胞癌

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Qian Song¹, Xiang Zhang¹, Weixin Liu¹

¹Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Hong Kong SAR, China.

Journal of hepatology

|July 17, 2023

概括

益益的肠道细菌Bifidobacterium pseudolongum可以预防非酒精性脂肪肝疾病相关的肝癌 (NAFLD-HCC). 它产生乙酸,该乙酸通过肠肝轴向肝细胞,以抑制瘤生长.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
在瘤学瘤学.

背景情况:

与非酒精性脂肪肝相关的肝细胞癌 (NAFLD-HCC) 是一个日益严重的全球健康问题.
肠道微生物群及其代谢物在NAFLD-HCC的发展中起着至关重要的作用.
需要针对NAFLD-HCC制定有效的预防策略.

研究的目的:

为了确定有利于NAFLD-HCC预防的细菌物种.
调查Bifidobacterium pseudolongum在NAFLD-HCC中的作用.
阐明B. pseudolongum通过何种机制发挥其保护作用.

主要方法:

我们使用了NAFLD-HCC的两种小鼠模型.
没有细菌的小鼠被用于对B. pseudolongum的代谢研究.
进行了代谢分析和细胞共同培养试验.

主要成果:

在小鼠中,B. pseudolongum的使用抑制了NAFLD-HCC的形成.
B. 伪长度受条件的介质抑制了NAFLD-HCC细胞增殖和诱导的亡.
乙酸被确定为这些抗瘤作用的关键代谢物.
B. pseudolongum恢复了肠道微生物组的平衡,并改善了肠道屏障功能.
乙酸通过肝细胞上的GPR43受体起作用,抑制IL-6/JAK1/STAT3信号通路.

结论:

B. pseudolongum通过产生抗瘤代谢物酸盐来保护NAFLD-HCC.
乙酸通过激活肝脏GPR43.3通过肠肝轴调解其作用.
B. pseudolongum显示出作为预防NAFLD-HCC的益生菌的显著潜力.

关键词:

乙酸乙酸盐的使用方法 B. 伪长 (Pseudolongum) 是一种类型.微生物群中的微生物群.这是NAFLD-HCC.益生菌益生菌益生菌

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