在NHANES,2007-2016年成年人中暴露于酸盐和类风湿性关节炎风险之间的关联
Ning Sheng1, Jie Wang1, Fei Xing1
1Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chemosphere
|July 17, 2023
概括
接触酸盐,常见的化学添加剂,与成人类风湿性关节炎 (RA) 的更高患病率有关. 这种关联在男性和老年人中特别强烈.
科学领域:
- 环境健康 环境健康
- 类风湿病学 类风湿病学
- 毒理学 毒理学 毒理学
背景情况:
- 类风湿性关节炎 (RA) 的病因是多因素的,涉及遗传和环境因素.
- 酸盐是广泛使用的化学添加剂,对其RA影响的研究有限.
- 这项研究评估了成年人甲酸盐暴露与类风湿性关节炎风险之间的关联.
研究的目的:
- 调查甲酸盐暴露与患类风湿性关节炎的风险之间的潜在联系.
- 评估剂量反应关系和特定酸盐与RA之间的非线性关联.
- 根据性别和年龄,探索甲酸盐-RA协会中的子组差异.
主要方法:
- 从2007-2016年国家健康和营养检查调查 (NHANES) 中分析了9322名成年参与者 (年龄≥20岁).
- 采用多变量逻辑回归模型来检查甲酸盐-RA关联.
- 非线性关系的特征是使用平滑曲线配件和通用添加模型,并根据性别和年龄对子组进行分析.
主要成果:
- 随着MECPP,MBP,MEHHP和MEOP暴露量较高,观察到RA患病率的增加.
- 在MECPP,MEHHP水平和RA之间发现了显著的非线性正相关性.
- 亚组分析表明,在男性和60岁以上的个体中,甲酸盐-RA相关性更明显.
结论:
- 甲酸暴露与成年人类类风湿性关节炎的患病率增加有关.
- 酸盐和RA之间的关联在男性和老年人群中更为显著.
- 这些发现突出了环境因素,特别是酸盐,作为RA发展的潜在贡献者.
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